Is Mean Radiation Dose to the Subventricular Zone a Prognostic Indicator?
نویسندگان
چکیده
منابع مشابه
Lateral ventricule invasion and radiation dose to subventricular zone: Their impact to the treatment outcomes of glioblastoma
Background: This study was conducted to evaluate the recurrence patterns of GBM in regard to its contact with LVs, the relation between radiation doses to subventrivular zone (SVZ). Materials and Methods: Between 2012 and 2014, 80 adult patients with GBM were included this trial. Median follow-up period was 15 months. Median tumor size was 4.5 cm (1.3-8 cm), where 58% of the patients had a tumo...
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PURPOSE Cancer stem cells (CSCs) may play a role in the recurrence of glioblastoma. They are believed to originate from neural stem cells in the subventricular zone (SVZ). Because of their radioresistance, we hypothesized that high doses of radiation (>59.4 Gy) to the SVZ are necessary to control CSCs and improve progression-free survival (PFS) or overall survival (OS) in glioblastoma. METHOD...
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PURPOSE Neural progenitor cells in the subventricular zone (SVZ) have a controversial role in glioblastoma multiforme (GBM) as potential tumor-initiating cells. The purpose of this study was to examine the relationship between radiation dose to the SVZ and survival in GBM patients. METHODS AND MATERIALS The study included 116 patients with primary GBM treated at the Johns Hopkins Hospital bet...
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Glioblastoma multiforme (GBM), a highly aggressive brain cancer characterized by uncontrolled proliferation, resistance to cell death, angiogenesis, and vascular edema, remains one of the deadliest types of cancer. The subventricular zone (SVZ) harbors cells with great proliferative potential, and the microenvironment within the SVZ is permissive to growth and proliferation. This neurogenic nic...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2017
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2017.06.748